James Phillip Lash

Spatial proteomics identifies altered thick ascending limb cells as drivers of kidney disease through uromodulin retention

This study identifies altered thick ascending limb cells with UMOD retention as drivers of CKD using spatial proteomics and shows reducing UMOD retention attenuates CKD development.

Cellular and Spatial Drivers of Unresolved Injury and Functional Decline in the Human Kidney

The paper presents a multi-modal atlas of human kidney disease, identifying cellular and spatial mechanisms of injury resolution or failure and linking them to clinical outcomes.

Genetics of cardiovascular outcomes in individuals with chronic kidney disease: the Chronic Renal Insufficiency Cohort (CRIC) study

The paper performs GWAS on cardiovascular outcomes in CKD patients, identifying stroke-associated SNVs but not replicating CHD findings, and finding genetic correlations with published GWAS.

Admixture mapping screening of CKD traits and risk factors in U.S. Hispanic/Latino individuals from Central America country-of-origin

The paper identifies ancestry-derived loci associated with CKD traits and risk factors in U.S. Hispanic/Latino individuals of Central American origin using admixture mapping.

Genome-wide admixture mapping of eGFR and CKD identify European and African ancestry-of-origin loci in U.S. Hispanics/Latinos

This study uses admixture mapping to identify ancestry-specific loci associated with eGFR and CKD in U.S. Hispanics/Latinos and validates findings in African Americans.