CHCHD2 mutant mice display mitochondrial protein accumulation and disrupted energy metabolism
Szu-Chi Liao, Kohei Kano, Sadhna Phanse, Mai K. Nguyen, Elyssa B. Margolis, YuHong Fu, Jonathan Xianglong Meng, Mohamed Taha Moutaoufik, Zac Chatterton, Tatiana D. Saccon, Kirsten Broderick, Hiroyuki Aoki, Jeffrey A. Simms, Felicia Xaveria Suteja, Yoshitaka J. Sei, , Ken Nakamura
This study generates CHCHD2 T61I mutant mice to model Parkinson's disease, finding mitochondrial dysfunction and metabolic shifts towards glycolysis.
Science Advances · Nov 14, 2025Peer-reviewedNeuroscience