Jeffrey A. Simms

Calcium-dependent synaptic proteomics reveals EGFR signaling at active synapses

The paper develops a method to profile synaptic proteomes under physiological conditions and identifies EGFR signaling as a key activity-dependent process at synapses.

Resilience to neuronal hyperactivity and restoration of the neuroimmune interactome by blocking fibrin-induced microglia activation in Alzheimers disease

This study shows that blocking fibrin-induced microglia activation reduces neuronal hyperactivity and restores the neuroimmune interactome in Alzheimer's disease.

TOMM40 suppression promotes neuronal cholesterol imbalance and molecular and behavioral phenotypes of Alzheimer's disease

This study shows that TOMM40 suppression leads to cholesterol imbalance and AD-like molecular and behavioral changes in mice and human neurons.

The GluA1 cytoplasmic tail regulates intracellular AMPA receptor trafficking and synaptic transmission onto dentate gyrus GABAergic interneurons, gating response to novelty

This study investigates the role of the GluA1 cytoplasmic tail in AMPA receptor trafficking and synaptic transmission in dentate gyrus GABAergic interneurons, revealing its impact on behavior and neuronal activity.

CHCHD2 mutant mice display mitochondrial protein accumulation and disrupted energy metabolism

This study generates CHCHD2 T61I mutant mice to model Parkinson's disease, finding mitochondrial dysfunction and metabolic shifts towards glycolysis.

Data-driven discovery of cell-type-directed network-correcting combination therapy for Alzheimer's disease

The paper identifies a cell-type-directed combination therapy for Alzheimer's disease using single-cell transcriptomics and drug databases, showing improved memory and reduced pathologies in a mouse model.

Sex-specific role for the long noncoding RNA Pnky in mouse behavior

This study shows that the lncRNA Pnky has sex-specific effects on mouse behavior, with male and female knockout mice displaying distinct behavioral deficits that can be reversed by a transgenic Pnky expression.