YuHong Fu

This study identifies a bidirectional pathogenic relationship between alpha-synuclein and neuromelanin in Parkinson's disease, showing they promote each other's accumulation and neuronal loss.

The paper identifies astrocytes as a key site of dsRNA accumulation and ADAR1 p150 induction in Parkinson's disease, linking dsRNA sensing to complement activation in a cell-type-specific manner.

The paper identifies and maps GABAergic cell clusters in the human rostromedial tegmental nucleus (RMTg) and retrorubral fields (RRF) using immunohistochemistry and anatomical staining.

This study generates CHCHD2 T61I mutant mice to model Parkinson's disease, finding mitochondrial dysfunction and metabolic shifts towards glycolysis.

This paper standardises and automates the quantification of intracellular neuromelanin granules in human brain tissue sections using TruAI, revealing age-related changes in their properties.

The paper introduces MJF-14 PLA, a proximity ligation assay for detecting non-inclusion alpha-synuclein aggregates with high specificity and sensitivity, showing pathology precedes Lewy body formation in Parkinson's disease.

This paper develops an iPSC platform to rapidly generate alpha-synuclein inclusions and investigates their formation, subtypes, and molecular interactions.

This study shows that chronic hyperactivation of midbrain dopamine neurons leads to their preferential degeneration, suggesting increased neural activity may contribute to Parkinson's disease pathology.