Author

Yoshitaka J. Sei

Gladstone InstitutesORCID 0000-0002-4725-8725Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Assay:proteomics· 1 Assay:spatial transcriptomics· 1

Frequent Co-Authors

Ken NakamuraiD· 3 shared Elyssa B. MargolisiD· 2 shared Glenda Margaret HallidayiD· 2 shared Kohei KanoiD· 2 shared Szu-Chi LiaoiD· 2 shared YuHong FuiD· 2 shared Zac ChattertoniD· 2 shared Alexandra NelsoniD· 1 shared

Activity by Year

2023-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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3 shared papersNeuroscience

Ken NakamuraORCID

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3 papers

Recent·Most cited

CHCHD2 mutant mice display mitochondrial protein accumulation and disrupted energy metabolism

Szu-Chi Liao, Kohei Kano, Sadhna Phanse, Mai K. Nguyen, Elyssa B. Margolis, YuHong Fu, Jonathan Xianglong Meng, Mohamed Taha Moutaoufik, Zac Chatterton, Tatiana D. Saccon, Kirsten Broderick, Hiroyuki Aoki, Jeffrey A. Simms, Felicia Xaveria Suteja, Yoshitaka J. Sei, , Ken Nakamura

This study generates CHCHD2 T61I mutant mice to model Parkinson's disease, finding mitochondrial dysfunction and metabolic shifts towards glycolysis.

Science Advances · Nov 14, 2025Peer-reviewedNeuroscience

Chronic hyperactivation of midbrain dopamine neurons causes preferential dopamine neuron degeneration

Katerina Rademacher, Zak Doric, Dominik Haddad, Aphroditi A. Mamaligas, Szu-Chi Liao, Rose B. Creed, Kohei Kano, Zac Chatterton, YuHong Fu, Joseph H. Garcia, Victoria Vance, Yoshitaka J. Sei, Anatol C. Kreitzer, Glenda Margaret Halliday, Alexandra Nelson, , Ken Nakamura

This study shows that chronic hyperactivation of midbrain dopamine neurons leads to their preferential degeneration, suggesting increased neural activity may contribute to Parkinson's disease pathology.

bioRxiv · Apr 5, 2024Neuroscience

Paradoxical mTORC1-Dependent microRNA-mediated Translation Repression in the Nucleus Accumbens of Mice Consuming Alcohol Attenuates Glycolysis

Yann Ehinger, Sophie Laguesse, Khanhky Phamluong, Alexandra Salvi, Yoshitaka J. Sei, Zachary W. Hoisington, Drishti Soneja, Sowmya Gunasekaran, Ken Nakamura, Dorit Ron A

The paper shows that mTORC1 activation in the nucleus accumbens of alcohol-consuming mice represses glycolysis via miR-34a-5p-mediated translation repression of Aldolase A, leading to reduced L-lactate and decreased alcohol intake.

bioRxiv · Nov 29, 2023 · PreprintNeuroscience