Zac Chatterton

This study identifies a bidirectional pathogenic relationship between alpha-synuclein and neuromelanin in Parkinson's disease, showing they promote each other's accumulation and neuronal loss.

This study identifies Netrin-1 as a DA-specific cue that enhances graft integration and functional recovery in Parkinsonian models without off-target effects.

This study generates CHCHD2 T61I mutant mice to model Parkinson's disease, finding mitochondrial dysfunction and metabolic shifts towards glycolysis.

This paper standardises and automates the quantification of intracellular neuromelanin granules in human brain tissue sections using TruAI, revealing age-related changes in their properties.

This study shows that chronic hyperactivation of midbrain dopamine neurons leads to their preferential degeneration, suggesting increased neural activity may contribute to Parkinson's disease pathology.

Peripheral blood-derived cells can be employed to stratify Parkinson's disease patients most likely to respond to LRRK2-related therapeutics.

The paper introduces a single-cell DNA methylation sequencing method that improves resolution and accuracy compared to existing techniques.

The paper identifies brain-derived circulating cell-free DNA as a peripheral biomarker specific to cell-type and brain-region origins in neurotrauma and neurodegeneration.