CIRCUST reconstructs temporal order of molecular rhythms from single timepoint data, validated on controlled experiments and applied to GTEx tissues to build a human daily rhythm gene expression atlas.

PLoS Computational Biology · Sep 28, 2023Peer-reviewedBioinformatics

A Novel Home-Based Study of Circadian Rhythms: Design, Rationale, and Methods for the Circadia Study.

Irma Vlasac, Gregory Bormes, Elizabeth Do, Selma S Benkhoukha, Naby Diallo, Noah L Fryou, Siena Gioia, Oluwaseun Akeju, Clarence Joseph, Anne Kuan, Jennifer Lapan, David Oluwadara, the Pepper Team, Shadab A. Rahman, Richa Saxena, , Jacqueline M. Lane

The Circadia Study investigates circadian rhythm disorders through a home-based approach to collect data and improve understanding of their genetics and treatment.

SLEEP · Jul 20, 2023Peer-reviewedGenetic & Genomic Medicine

Genome-wide association analysis of excessive daytime sleepiness identifies 42 loci that suggest phenotypic subgroups

Heming Wang, Jacqueline M. Lane, Samuel E. Jones, Hassan S. Dashti, Hanna Maria Ollila, Andrew R. Wood, Vincent T. van Hees, Ben Michael Brumpton, Bendik Slagsvold Winsvold, Katri Kantojärvi, Teemu Palviainen, Brian E. Cade, Tamar Sofer, Yanwei Song, Krunal Patel, , Richa Saxena

This study identifies 42 genetic loci associated with excessive daytime sleepiness and links them to phenotypic subgroups and related traits.

Nature Communications · Aug 13, 2019Peer-reviewedGenomics

GWAS in 446,118 European adults identifies 78 genetic loci for self-reported habitual sleep duration supported by accelerometer-derived estimates

Hassan S. Dashti, Samuel E. Jones, Andrew R. Wood, Jacqueline M. Lane, Vincent T. van Hees, Heming Wang, Jessica A. Rhodes, Yanwei Song, Krunal Patel, Simon George Anderson, Robin N. Beaumont, David A. Bechtold, Jack Bowden, Brian E. Cade, Marta Garaulet, , Richa Saxena

Nature Communications · Mar 7, 2019Peer-reviewedGenetics

Biological and clinical insights from genetics of insomnia symptoms

HUNT All In Sleep, Jacqueline M. Lane, Samuel E. Jones, Hassan S. Dashti, Andrew R. Wood, Krishna G. Aragam, Vincent T. van Hees, Linn Beate Strand, Bendik Slagsvold Winsvold, Heming Wang, Jack Bowden, Yanwei Song, Krunal Patel, Simon George Anderson, Robin N. Beaumont, , Richa Saxena

The paper identifies 57 genomic regions associated with insomnia symptoms, linking them to phototransduction, ubiquitination, and potential causal relationships with coronary heart disease and depression.

Nature Genetics · Feb 25, 2019Peer-reviewedGenomics

Genome-wide association analyses of sleep disturbance traits identify new loci and highlight shared genetics with neuropsychiatric and metabolic traits

Jacqueline M. Lane, Jingjing Liang, Irma Vlasac, Simon George Anderson, David A. Bechtold, Jack Bowden, Richard Emsley, Shubhroz Gill, Max A. Little, Annemarie Ida Luik, Andrew S. I. Loudon, Frank A. J. L. Scheer, Shaun Purcell, Simon David Kyle, Debbie A. Lawlor, , Richa Saxena

This study identifies new genetic loci associated with sleep disturbance traits and finds shared genetic links with neuropsychiatric and metabolic traits.

Nature Genetics · Dec 19, 2016Peer-reviewedGenetics