Thomas Dresbach

Establishing synthetic ribbon-type active zones in a heterologous expression system

The paper reconstitutes synthetic ribbon-type active zones in HEK293 cells using Bassoon, RIBEYE, and CaV1.3 channels, showing structural and functional similarities to native ribbons.

3D MINFLUX combined with DNA-PAINT resolves the arrangement of Bassoon at active zones

The paper uses 3D MINFLUX and DNA-PAINT to determine the orientation of Bassoon at active zones with 5 nm precision, showing its C-terminal faces the synaptic cleft and N-terminal faces synaptic vesicles.

A correlative workflow streamlines synaptic imaging by cryo-electron tomography

The paper develops a correlative cryo-light/electron microscopy workflow to target and image synapses with cryo-ET, revealing excitatory synapses.

The synaptic vesicle protein Mover/TPRG1L is associated with lipid droplets in astrocytes

The paper identifies Mover/TPRG1L as a lipid droplet protein in astrocytes and shows its role in lipid droplet accumulation and targeting.

Nanoscopical analysis reveals an orderly arrangement of the presynaptic scaffold protein Bassoon at the Golgi-apparatus

The paper uses STED nanoscopy to show Bassoon is an extended protein at the Golgi-apparatus with its N-terminus near the trans-Golgi network and C-terminus away from it.

Increased synaptic facilitation and exploratory behavior in mice lacking the presynaptic protein Mover

This study investigates the role of the vertebrate-specific presynaptic protein Mover in synaptic transmission and behavior, finding increased synaptic facilitation and reduced anxiety in Mover knockout mice.

Neuroligins mediate presynaptic maturation through brain-derived neurotrophic factor signaling

This study shows that BDNF signaling works with Neuroligins to promote presynaptic maturation and synapse formation.