Author

Alfonso Lavado

St. Jude Children's Research Hospital

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Developmental Biology· 2 Animal Behavior & Cognition· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 4 Research Focus:cell type annotation· 3 Research Focus:differential expression· 2 Approach:experimental assay· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

Joshua Paré· 2 shared Xinwei CaoiD· 2 shared Yong‐Dong WangiD· 2 shared Adam David DurbiniD· 1 shared Akhilesh Mishra· 1 shared Alisha KardianiD· 1 shared Amanda BlandiD· 1 shared Amelia Hancock· 1 shared

Activity by Year

2021-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersDevelopmental Biology

Joshua Paré

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Preclinical evaluation of antisense oligonucleotide therapy in a mouse model of HNRNPH2-related neurodevelopmental disorder

Ané Korff, Xiaojing Yang, Ozan Ozdemir, Ananya Samanta, Yong‐Dong Wang, Tushar Patni, Alfonso Lavado, Anoop Murthy Kavirayani, Joseph Ochaba, Berit E. Powers, C. Frank Bennett, Hong Joo Kim, J. Paul Taylor

This study tests antisense oligonucleotides targeting Hnrnph2 in a mouse model, showing reduced Hnrnph2 levels, increased Hnrnph1, and improved phenotypes like seizures and motor function.

Science Translational Medicine · Apr 22, 2026Peer-reviewedAnimal Behavior & Cognition

Dominant Malignant Clones Leverage Lineage Restricted Epigenomic Programs to Drive Ependymoma Development

Alisha Kardian, Hua Sun, Siri Manasa Ippagunta, Nic Laboe, Srinidhi Varadharajan, Kwanha Yu, Hsiao‐Chi Chen, Erik Emanus, Tuyu Zheng, Riley M. Deneen, Jon P. Connelly, Yong-Dong Wang, Jiangshan Zhan, Hengxi Liu, Kimberley Lowe, , Stephen C. Mack

This study identifies specific developmental epigenomic states that enable ZFTA-RELA-driven ependymoma formation and reveals how these states shape tumor progression.

Nature · Mar 25, 2026Peer-reviewedCancer Biology

TEAD switches interacting partners along neural progenitor lineage progression to execute distinct functions

Charles H. Perry, Alfonso Lavado, Venkata Thulabandu, Cody A. Ramirez, Joshua Paré, Rajiv Dixit, Akhilesh Mishra, Jiyuan Yang, Jiyang Yu, Xinwei Cao

The paper shows TEAD1/2 have both YAP/TAZ-dependent and -independent roles in neural progenitor lineage progression, promoting progression by inhibiting Notch and cooperating with INSM1.

Genes & Development · Jul 1, 2025Peer-reviewedDevelopmental Biology

YAP/TAZ Maintain the Proliferative Capacity and Structural Organization of Radial Glial Cells During Brain Development

Alfonso Lavado, Ruchika Gangwar, Joshua Paré, Shibiao Wan, Yiping Fan, Xinwei Cao

This study shows YAP/TAZ are essential for maintaining radial glial cell function during brain development, affecting neuronal and ependymal cell numbers and causing hydrocephaly when disrupted.

Developmental Biology · Aug 19, 2021Peer-reviewedDevelopmental Biology