Zoltán Lipinszki

Functionally dark genes and the transcriptomic landscape of sporulation in a model mushroom-forming fungus

This study identifies novel genes and transcriptomic changes during sporulation in Coprinopsis cinerea, highlighting functionally dark genes involved in spore formation.

Coordinated regulation of Barrier-to-Autointegration Factor (BAF) phosphorylation by protein phosphatases PP2A and PP4

This study identifies PP2A as the main phosphatase for BAF dephosphorylation in interphase and shows PP4's role in maintaining centromeric BAF in an unphosphorylated state during mitosis.

Intrahepatic reporter assay reveals leaky somatic blockade of L1 retrotransposition in mice

The paper demonstrates somatic L1 retrotransposition in adult mouse liver using an intrahepatic reporter assay and identifies distinct regulatory mechanisms in tumor versus normal cells.

Functional characterization of a Con7-related transcription factor in Coprinopsis cinerea indicates evolutionary conservation of morphogenetic roles

This study characterizes GCD1, a Con7-related transcription factor in Coprinopsis cinerea, showing its role in fruiting body morphogenesis and evolutionary conservation across fungi.

A new regulator of sporulation sheds light on spore morphogenesis and ballistospory in mushroom-forming fungi

This study identifies SRR1 as a conserved regulator of sporulation and ballistospory in mushroom-forming fungi, revealing its role in spore morphogenesis and identifying downstream targets.

Evidencing the role of a conserved polar signaling channel in the activation mechanism of the u-opioid receptor

The paper investigates the role of a conserved polar signaling channel in the activation of the mu-opioid receptor through mutations and simulations, showing its critical role in agonist binding and G protein stimulation.

Retracing the horizontal transfer of a novel innate immune factor in Drosophila

This study uses genome editing in Drosophila to trace the evolution of horizontally transferred immune toxins, showing fusionB enhances survival and suppresses parasitoid wasp development.

Versatile gamma-tubulin complexes contribute to the dynamic organization of MTOCs during Drosophila spermatogenesis

The paper investigates the distribution and interactions of gamma-tubulin complex proteins in Drosophila spermatogenesis, revealing their roles in organizing diverse MTOCs during cell organelle rearrangement.

Distinct components of nucleoside-modified messenger RNA vaccines cooperate to instruct efficient germinal center responses

This study identifies distinct roles of nucleoside-modified mRNA and lipid nanoparticles in promoting Tfh cell responses through different mechanisms.

Enhancing the translational capacity of E. coli by resolving the codon bias

This paper introduces a strain of E. coli that overexpresses rare tRNA genes to overcome codon bias, improving protein expression efficiency.