Ying K. Tam

Rapid vaccine induction of macaque HIV-1 V2 Apex broadly neutralizing antibodies with immunogenetic signatures that are potentially translatable to humans

This study shows that vaccination of macaques with an Env-ferritin nanoparticle rapidly elicits V2-apex broadly neutralizing antibodies with immunogenetic features that may be applicable to humans.

Clonal dynamics of germinal center refueling by secondary immunization

This study investigates how booster immunizations affect germinal center (GC) clonality in mice, finding that refueling leads to clonal expansion rather than memory recruitment.

Computationally designed mRNA-launched protein nanoparticle vaccines

This paper develops an mRNA-launched nanoparticle vaccine that combines protein nanoparticle and mRNA vaccine advantages, showing enhanced antibody and T cell responses in mice.

mRNA-LNP vaccines against Hepatitis B virus induce protective immune responses in preventive and chronic mouse challenge models

This study shows mRNA-LNP vaccines against HBV induce strong immune responses in both preventive and chronic infection models in mice.

An IL-12 mRNA-LNP adjuvant enhances mRNA vaccine induced CD8+ T cell responses

This study shows that adding IL-12 mRNA-LNPs to an mRNA vaccine enhances CD8+ T cell responses against model antigens and improves protection against infections and tumors.

The type I IFN-IL-27 axis promotes mRNA vaccine-induced CD8+ T cell responses

This study shows that IL-27, induced by mRNA-LNP vaccines, enhances CD8+ T cell responses through type I IFN signaling, improving vaccine efficacy against pathogens and tumors.

Distinct components of nucleoside-modified messenger RNA vaccines cooperate to instruct efficient germinal center responses

This study identifies distinct roles of nucleoside-modified mRNA and lipid nanoparticles in promoting Tfh cell responses through different mechanisms.