Mark L. Andermann

EASI-PASS: An accessible pipeline for linking functional imaging and mRNA profiling

Matching cell masks between two-photon calcium images and thick, expanded EASI-FISH volumes recovers molecular identity for 72% (slice) to 83% (in vivo) of imaged neurons on conventional microscopes.

Simultaneous, real-time tracking of many neuromodulatory signals with Multiplexed Optical Recording of Sensors on a micro-Endoscope

This paper develops a micro-endoscope probe to simultaneously track multiple neuromodulators in real time using fluorescent sensors, demonstrating its use in brain slices and awake mice.

Rapid fluorescence lifetime sensor development of LifeCamp enables transient and baseline absolute calcium measurements

This paper introduces LifeCamp, a high-speed calcium lifetime sensor developed using RALISED, enabling accurate measurement of baseline and transient calcium levels in neurons.

Noradrenergic Modulation of an Amygdalo-thalamic Circuit

The paper investigates how norepinephrine modulates synaptic transmission from the basolateral amygdala to the mediodorsal thalamus, revealing its role in suppressing affective information transfer during stress.

Obesity dysregulates feeding-evoked response dynamics in hypothalamic satiety neurons

This study shows that obesity alters the response dynamics of hypothalamic satiety neurons to food consumption, with high-fat diet-fed animals showing exaggerated early responses and reduced response progression during meals.

Slow-Timescale Regulation of Dopamine Release and Mating Drive over Days

The paper investigates how dopamine transmission and mating drive change over days in male mice, finding two mechanisms that regulate these slow-timescale dynamics.

Brainstem sensing of multiple body signals during food consumption

The paper maps neural activity in the mouse brainstem during food consumption, showing how different body signals are integrated across spatially clustered neurons.

Competition between stochastic neuropeptide signals calibrates the rate of satiation

The paper shows how stochastic neuropeptide signals (NPY and MSH) compete to regulate cAMP levels in neurons, influencing satiation through state-dependent integration.

Cortical Reactivations Modulated by Local InhibitoryCircuits Mediate Memory Consolidation

The paper shows that reactivations in the lateral visual cortex are essential for visual association learning consolidation, with inhibitory neuron manipulation reducing cue-specific reactivations and learning.

A spatially-resolved transcriptional atlas of the murine dorsal pons at single-cell resolution

This study creates a spatially-resolved transcriptional atlas of the murine dorsal pons using snRNA-seq and MERFISH, identifying 120 neuronal subtypes and their spatial distribution.

Transient cAMP production drives rapid and sustained spiking in brainstem parabrachial neurons tosuppress feeding

The paper shows that transient cAMP production in brainstem parabrachial neurons suppresses feeding for minutes, matching the duration of cAMP and calcium activity elevations.

Cortical reactivations predict future sensory responses

The paper shows that cortical reactivations predict future sensory responses and representational drift in mice.

Sensory cortical ensembles exhibit differential coupling to ripples in distinct hippocampal subregions

The paper identifies cortical neuron ensembles that couple differently to hippocampal SWRs in distinct subregions and proposes their role in cognitive map formation.

Sensitization of meningeal afferents to locomotion-related meningeal deformations in a migraine model

This study investigates how meningeal afferents respond to locomotion-related deformations in a migraine model, finding that CSD enhances sensitivity to these deformations.

A collaboration between immune cells and the choroid plexus epithelium in brain inflammation

The paper shows the ChP acts as an immune organ in brain inflammation, with immune cell interactions and epithelial cell specialization regulating the barrier.

Chronic stress triggers seeking of a starvation-like state in anxiety-prone female mice

This study shows chronic stress can lead anxious female mice to prefer a starvation-like state induced by AgRP neuron activation.

Visual association cortex links cues with conjunctions of reward and locomotor contexts

The paper tracks POR neuron responses in mice during learning to show how neurons encode cues in specific reward and locomotion contexts.

Dopamine-dependent cAMP dynamics in basal amygdala glutamatergic neurons

The paper investigates dopamine-dependent cAMP dynamics in basal amygdala glutamatergic neurons during salient events, showing that cAMP responses decay more slowly than dopamine release and exhibit depression with repeated stimulation.

Selective gating of retinal information by arousal

This study shows that arousal modulates visual responses in retinal axons of awake mice, with differential effects based on stimulus frequency, spatial location, and motion direction.

State-specific gating of salient cues by midbrain dopaminergic input to basal amygdala

The paper investigates how midbrain dopaminergic input to the basal amygdala gates responses to salient cues during learning in mice.

Distinct neuronal activity patterns induce different gene expression programs

The paper shows that distinct neuronal activity patterns induce different gene expression programs through specific mechanisms.