Surya Chandra Rao Thumu

Astrocyte-oligodendrocyte crosstalk dependent myelination via secreted protein YKL40

This study identifies YKL40 as a secreted protein mediating astrocyte-OPC communication to drive myelination during brain development.

Aberrant neuronal differentiation and splicing defects in Congenital Myotonic Dystrophy (DM1) iPSC models

This study investigates neuronal differentiation and splicing defects in congenital DM1 iPSC models, revealing precocious differentiation and mis-splicing in key genes.

Sphingosine-1-Phosphate Receptor 1 regulates competition dependent astrocyte morphogenesis and tiling in murine cortex.

This study shows that S1PR1 regulates astrocyte morphogenesis and tiling in the developing murine cortex through competition and JAK-STAT3 signaling.

SRF-deficient astrocytes provide neuroprotection in mouse models of excitotoxicity and neurodegeneration

This study shows that deleting SRF in astrocytes creates neuroprotective astrocytes that reduce neuronal damage in mouse models of excitotoxicity and neurodegenerative diseases.

Zic3 enables bimodal regulation of tyrosine hydroxylase expression in dopaminergic neurons of olfactory bulb and midbrain

This study identifies ZIC3 as a key regulator of tyrosine hydroxylase expression in dopaminergic neurons of the olfactory bulb and midbrain through dual regulatory mechanisms.

Automated Morphometric Analysis Reveals Plasticity Induced by Chronic Antidepressant Treatment in Hippocampal Astrocytes

The paper introduces SMorph, a tool for automated morphometric analysis of nervous system cells, revealing structural remodeling in hippocampal astrocytes after chronic antidepressant treatment.