Shaun R. Brinsmade

In Staphylococcus aureus, MbcS is a refunctionalized acyl-CoA synthetase that confers a fitness advantage during intra-species competition

This paper identifies MbcS as a refunctionalized acyl-CoA synthetase in S. aureus that enhances fitness during intra-species competition by enabling BCFA precursor scavenging under nutrient limitation.

Pyrimidine sufficiency is required for Sae two-component system signaling in Staphylococcus aureus

This study shows that pyrimidine biosynthesis is essential for SaeS kinase activity in S. aureus, linking nucleotide metabolism to virulence regulation through membrane integrity.

CodY controls the SaeR/S two-component system by modulating branched-chain fatty acid synthesis in Staphylococcus aureus

This paper identifies how CodY regulates the SaeRS two-component system in S. aureus by modulating branched-chain fatty acid synthesis through the ilv-leu operon and brnQ2 gene.

Discovery of an anti-virulence compound that targets the Staphylococcus aureus SaeRS two-component system to inhibit toxic shock syndrome toxin 1 (TSST-1) production

The paper identifies PP-HCl as an anti-virulence compound that inhibits TSST-1 production in S. aureus without affecting bacterial growth or vaginal microbiota.