All-optical electrophysiology in hiPSC-derived neurons with synthetic voltage sensors
Francesca Puppo, Sanaz Sadegh, Cleber A. Trujillo, Martin Thunemann, Evan P. Campbell, Matthieu Vandenberghe, Xiwei Shan, Ibrahim A. Akkouh, Evan W. Miller, Brenda L. Bloodgood, Gabriel A. Silva, Anders Martin Dale, Gaute T. Einevoll, Srdjan Djurovic, Ole A. Andreassen, , Anna Devor
The paper introduces a synthetic voltage sensor and optogenetic actuator for all-optical electrophysiology in hiPSC-derived neurons, demonstrating its effectiveness in measuring activity across distinct genetic backgrounds.
Frontiers in Cellular Neuroscience · May 28, 2021Peer-reviewedNeuroscience