Author

Xiwei Shan

University of California San DiegoPrimary ORCID profile (0000-0002-3829-8143 · 4 papers)Unclaimed ORCID profile · follow to get notified of new preprints

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Same name, identified by ORCID

Xiwei ShaniD4 papers · Genentech

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Assay:electronic health records· 1

Frequent Co-Authors

Alysson Renato MuotriiD· 2 shared Adriano FerrasaiD· 1 shared Allen Y Wang· 1 shared Alon GoreniD· 1 shared Anders Martin DaleiD· 1 shared Angels Almenar‐QueraltiD· 1 shared Anju SinghiD· 1 shared Anna DevoriD· 1 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersNeuroscience

Alysson Renato MuotriORCID

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2 papers

Recent·Most cited

SETD5 dysfunction in human astrocytes drives IL-6-mediated neuronal impairments via the JAK/STAT signaling pathway

Angels Almenar‐Queralt, Isabella Rodrigues Fernandes, Janaina S de Souza, Anju Singh, Xiwei Shan, Georgia Chaldaiopoulou, Dylan Phan, Kelsey L. Dang, Max W. Chang, Adriano Ferrasa, Noel T Southall, Luisa Bulcao Vieira Coelho, Livia Luz S Nascimento, Brett Taylor, Miguel F. Tenreiro, , Alysson Renato Muotri

This study shows that SETD5 dysfunction in astrocytes increases IL-6, which harms neurons via JAK/STAT signaling, suggesting therapeutic targeting of this pathway for ASD and ID.

bioRxiv · Jul 28, 2026 · PreprintNeuroscience

All-optical electrophysiology in hiPSC-derived neurons with synthetic voltage sensors

Francesca Puppo, Sanaz Sadegh, Cleber A. Trujillo, Martin Thunemann, Evan P. Campbell, Matthieu Vandenberghe, Xiwei Shan, Ibrahim A. Akkouh, Evan W. Miller, Brenda L. Bloodgood, Gabriel A. Silva, Anders Martin Dale, Gaute T. Einevoll, Srdjan Djurovic, Ole A. Andreassen, , Anna Devor

The paper introduces a synthetic voltage sensor and optogenetic actuator for all-optical electrophysiology in hiPSC-derived neurons, demonstrating its effectiveness in measuring activity across distinct genetic backgrounds.

Frontiers in Cellular Neuroscience · May 28, 2021Peer-reviewedNeuroscience