Francesca Puppo

A neurorecording toolkit for longitudinal assessments of transplanted human cortical organoids in vivo

This paper presents a neurorecording toolkit to longitudinally assess transplanted human cortical organoids in vivo, showing increased neuronal activity and synchronicity over time.

Multimodal monitoring of human cortical organoids implanted in mice using transparent graphene microelectrodes reveal functional connection between organoid and mouse visual cortex

The paper demonstrates functional connectivity between human cortical organoids and mouse visual cortex using transparent graphene microelectrodes and two-photon imaging.

Super-selective reconstruction of causal and direct connectivity with application to in-vitro iPSC neuronal networks

This paper introduces a method to accurately reconstruct direct and causal connectivity in in-vitro neuronal networks from multi-electrode array data, improving understanding of neural development and disease.

All-optical electrophysiology in hiPSC-derived neurons with synthetic voltage sensors

The paper introduces a synthetic voltage sensor and optogenetic actuator for all-optical electrophysiology in hiPSC-derived neurons, demonstrating its effectiveness in measuring activity across distinct genetic backgrounds.

Computing temporal sequences associated with dynamic patterns on the C. elegans connectome

The paper simulates dynamics on the C. elegans connectome and shows that most signaling pathways change when the network is embedded, suggesting caution in studying isolated circuits.

Splicing impact of deep exonic missense variants in CAPN3 explored systematically by minigene functional assay

The paper systematically assesses the splicing impact of deep exonic missense variants in CAPN3 using minigene assays, revealing that eight variants disrupt splicing and highlight limitations in current computational tools.