Cleber A. Trujillo

Cortical Organoids Model Early Brain Development Disrupted by 16p11.2 Copy Number Variants in Autism

This study uses cortical organoids derived from patients with 16p11.2 CNV to show altered neurodevelopmental processes, including changes in organoid size, neuronal maturation, and migration.

All-optical electrophysiology in hiPSC-derived neurons with synthetic voltage sensors

The paper introduces a synthetic voltage sensor and optogenetic actuator for all-optical electrophysiology in hiPSC-derived neurons, demonstrating its effectiveness in measuring activity across distinct genetic backgrounds.

Autism-linked Cullin3 germline haploinsufficiency impacts cytoskeletal dynamics and cortical neurogenesis through RhoA signaling

This study shows that Cul3 haploinsufficiency in mice causes social and cognitive deficits, cortical volume reduction, and cytoskeletal defects, which are rescued by RhoA inhibition.

Nested oscillatory dynamics in cortical organoids model early human brain network development

This paper shows that cortical organoids model early human brain network development by exhibiting oscillatory activity that transitions to patterns resembling preterm EEG.