This paper introduces a semi-automated protocol for isolating multiple liver cell types from mouse and human livers with high yield, purity, and viability.

bioRxiv · Jan 21, 2025 · PreprintCell Biology

Basal MET Phosphorylation is an Indicator of Hepatocyte Dysregulation in Liver Disease

Sebastian Burbano de Lara, Svenja Kemmer, Ina Biermayer, Svenja Feiler, Artyom Vlasov, Lorenza A. D’Alessandro, Barbara Helm, Christina Mölders, Yannik Dieter, Ahmed Ghallab, Jan Georg Hengstler, Christiane Körner, Madlen Matz‐Soja, Christina Götz, Georg Damm, , Ursula Klingmüller

The paper identifies elevated basal MET phosphorylation as a marker of hepatocyte dysregulation in liver disease, correlating with patient outcomes after surgery.

Molecular Systems Biology · Jan 12, 2024Peer-reviewedSystems Biology

Cell atlas of the regenerating human liver after portal vein embolization

Agnieska Brazovskaja, Tomás Gomes, Christiane Körner, Zhisong He, Theresa Schaffer, Julian Connor Eckel, René Hänsel, Małgorzata Santel, Timm Denecke, Michael Dannemann, Mario Brosch, Jochen Hampe, Daniel Seehofer, Georg Damm, J. Gray Camp, Barbara Treutlein

This study uses single-cell transcriptomics to analyze liver regeneration after portal vein embolization, identifying changes in cell states and immune interactions.

bioRxiv · Jun 3, 2021 · PreprintGenomics

Identification of Interleukin1β as an Amplifier of Interferon alpha-induced Antiviral Responses

Katharina Robichon, Tim Maiwald, Marcel Schilling, Annette Schneider, Joschka Willemsen, Florian Salopiata, Melissa Teusel, Salopiata, Clemens Kreutz, Christian Ehlting, Jun Huang, Sajib Chakraborty, Xiaoyun Huang, Georg Damm, Daniel Seehofer, , Ursula Klingmüller

This study identifies IL1β as an amplifier of IFN-induced antiviral responses through mathematical modeling and experimental validation.

PLoS Pathogens · Oct 1, 2020Peer-reviewedSystems Biology