The nucleus activates mechano-responsiveness via FHOD-associated LINC complexes
Susumu Antoku, Leroy C. Joseph, Prachi Dabhade, Xiaokan Zhang, Chyuan‐Sheng Lin, Thomas Schwartz, Jared Kushner, Barry M. Fine, John Morrow, Howard J. Worman, Gregg G. Gundersen
The paper shows the nucleus actively directs mechanical properties of actin cytoskeleton via FHOD-associated LINC complexes, and disruption causes cardiac hypertrophy.
bioRxiv · Jun 13, 2025 · PreprintCell Biology