Howard J. Worman

Lamin A/C depletion from myofibers and satellite cells in mice reveals selective muscle pathology

This study depletes lamin A/C in specific muscle cell types in mice, revealing that skeletal muscle satellite cells are critical for preventing lethal myopathy, while cardiomyopathy remains more invariant.

Prelamin A Does Not Promote Atherosclerosis or Vascular Smooth Muscle Loss

This study shows that prelamin A does not cause vascular smooth muscle loss or atherosclerosis, unlike progerin in HGPS.

The nucleus activates mechano-responsiveness via FHOD-associated LINC complexes

The paper shows the nucleus actively directs mechanical properties of actin cytoskeleton via FHOD-associated LINC complexes, and disruption causes cardiac hypertrophy.

Challenges associated with diagnostic exome sequencing in liver diseases

This study evaluates exome sequencing in liver diseases, finding a 5.7% diagnostic rate for monogenic disorders after filtering and manual review.