Leroy C. Joseph

This study depletes lamin A/C in specific muscle cell types in mice, revealing that skeletal muscle satellite cells are critical for preventing lethal myopathy, while cardiomyopathy remains more invariant.

This study shows that prelamin A does not cause vascular smooth muscle loss or atherosclerosis, unlike progerin in HGPS.

The paper shows the nucleus actively directs mechanical properties of actin cytoskeleton via FHOD-associated LINC complexes, and disruption causes cardiac hypertrophy.