Kael Dai

Circuit and cell-type mechanisms of the spectrolaminar motif of cortical oscillations

The paper uses a bio-realistic model of mouse primary visual cortex to show that cortical oscillations follow a spectrolaminar motif, with gamma in superficial layers and alpha/beta in deep layers, driven by specific cell types and synaptic properties.

Deep-learning-assisted simulation of a cortical circuit: integrating anatomy, physiology and function

The paper presents a deep-learning-assisted simulator of a mouse primary visual cortex model, integrating multimodal data to study circuit function and synaptic organization.

Uncovering circuit mechanisms of current sinksand sources with biophysical simulations ofprimary visual cortex

The paper uses biophysical simulations of mouse primary visual cortex to show that current sinks and sources are shaped by both synaptic weights and dendritic placement, with distinct contributions from thalamocortical inputs and cortical feedback.

A survey of spiking activity reveals a functional hierarchy of mouse corticothalamic visual areas

The paper presents a dataset and analysis of spiking activity across multiple mouse visual areas, revealing that functional connectivity mirrors anatomical hierarchy.

Brain Modeling ToolKit: an Open Source Software Suite for Multiscale Modeling of Brain Circuits

The paper introduces BMTK, an open-source software suite for multiscale brain circuit modeling, enabling simulations across different resolution levels with reduced coding requirements.

Systematic Integration of Structural and Functional Data into Multi-Scale Models of Mouse Primary Visual Cortex

The paper develops a multi-scale model of mouse primary visual cortex integrating structural and functional data to identify cell-class specific connectivity rules.

The SONATA Data Format for Efficient Description of Large-Scale Network Models

The paper introduces the SONATA data format to efficiently describe large-scale network models in neuroscience, enabling model construction, simulation, and sharing.

Molecular Nearest Neighbors Determine Generalization of Odorant Mixtures

The paper investigates how mice generalize responses to odorant mixtures by testing models that predict perceptual similarity based on molecular nearest neighbors.

h-channels contribute to divergent electrophysiological properties of supragranular pyramidal neurons in human versus mouse cerebral cortex

The paper shows that h-channels contribute to differences in electrophysiological properties between human and mouse supragranular pyramidal neurons.