Robust and accessible in situ sequencing with an open-source automated sequencer
Aixin Zhang, Zoe Maltzer, Jacob Lapka, Sabrina Cheng, Alan Guthrie, Cliff Slaughterbeck, Angela Y. Fan, Neha Goswami, Mara C.P. Rue, Maryam Majeed, Dennis M. Maharjan, Jeanelle Ariza, Angela P. Ayala, Madeleine Bixby, Cory T. Dickson, , Xiaoyin Chen
The paper introduces Seq-o-Matic, an open-source automated in situ sequencer that reduces hands-on time and improves sequencing consistency across tissue sections.
bioRxiv · Oct 23, 2026 · PreprintGenomics