Peter Chong

The paper presents an enhancer AAV toolbox for targeting and perturbing striatal cell types and circuits in mice, with validated specificity and cross-species applicability.

This study characterizes and simulates changes in human hippocampal granule cells during epilepsy progression, identifying ion channel modifications that increase excitability.

The paper identifies transcriptomic diversity in human supragranular neurons and links it to functional specialization and disease vulnerability.

The paper identifies enhancer elements that drive subclass-specific gene expression in neocortex across mouse, primate, and human species using comparative epigenetics and AAV-based functional assays.

The paper classifies neurons in mouse visual cortex into 17 electrophysiological and 35 morphological types using unsupervised methods and links them to transcriptomic types.

The paper shows that h-channels contribute to differences in electrophysiological properties between human and mouse supragranular pyramidal neurons.

This paper describes an ex vivo platform for studying adult human neocortical cell types and circuits using acute and cultured brain slices, enabling molecular-genetic manipulation and neuronal activity monitoring.