Chantal Combredet

Rapid repurposing of microvillar content drives a flagellate-to-amoeboid switch in the closest relative of animals

This study identifies rapid cytoskeletal remodeling in choanoflagellates during a flagellate-to-amoeboid switch, driven by microvillar retraction and actin cortex formation.

Environmentally regulated clonal-aggregative multicellularity in a choanoflagellate

This study shows that the choanoflagellate Choanoeca flexa forms multicellular sheets through clonal or aggregative mechanisms, adapting to environmental changes in splash pools.

Disabling a key viral innate immunity antagonist converts measles vaccine into RIG-I-driven cancer immunotherapy

This paper modifies a measles vaccine by removing a viral protein to create a cancer immunotherapy that activates the immune system via RIG-I signaling, leading to tumor regression in multiple models.

A fast and robust gene knockout method for Salpingoeca rosetta clarifies the genetics of choanoflagellate multicellular development

This paper introduces a fast and efficient gene knockout method for Salpingoeca rosetta, demonstrating its ability to disrupt multicellular development and reveal novel phenotypes.