David A. Scott

This paper reports the discovery of SBP-5917, a reversible FASN-TE inhibitor with submicromolar potency and cellular target engagement.

This study shows that intestinal Bacteroides species degrade tryptophan into indoles, which enhance anti-tumor immunity and limit melanoma growth.

This study identifies PI5P4K as a regulator of iron homeostasis in pancreatic cancer cells, showing its role in metabolic fitness and tumor growth.

This study develops ZBTB11 degraders to target metabolic vulnerabilities in K-Ras inhibitor-resistant PDAC, showing improved anti-cancer activity with reduced toxicity to neurons.

This study identifies LDHB as a key regulator of pDC IFN-I production and metabolic capacity during viral infection, linking metabolic deficiencies to pDC exhaustion and its dual role in immunity and pathology.

This study shows that macropinocytosis regulates CAF subtype identity under metabolic stress in PDAC, impacting tumor stroma and therapeutic response.

This paper develops genetically encoded fluorescent sensors to measure polyamine levels, uptake, and distribution in cells, revealing compounds that modulate polyamine levels.