Juan D. Navarro‐López

Structure-based identification of GIRK2-PIP2 modulators among known drugs and metabolites using docking, MM-GBSA, ADMET, and molecular dynamics

The paper screens over one million compounds to identify GIRK2-PIP2 modulators using docking, MM-GBSA, ADMET, and molecular dynamics.

Social and Contextual Memory Impairments Induced by Amyloid-β Oligomers are Rescued by Sigma-1 Receptor Activation

This study shows that activating sigma-1 receptors with PRE-084 rescues synaptic plasticity and memory impairments caused by amyloid-beta oligomers in an Alzheimer's disease model.

Low dose of a non-urea selective GIRK channel activator improves hippocampal-dependent synaptic plasticity and memory disrupted by amyloid-β oligomers

The paper tests a GIRK channel activator in AD models, finding low doses improve synaptic plasticity and memory without sex differences, while high doses impair function in healthy mice.

Mapping the spatial proteomic signature of dorsal and ventral hippocampus in a mouse model of early Alzheimer's disease: changes in synaptic plasticity-related proteins associated with sexual dimorphism

The paper maps spatial proteomic changes in dorsal and ventral hippocampus of male and female Alzheimer's disease models, identifying sex-dependent protein alterations linked to synaptic plasticity and GSK-3β activity.

BETA-HYDROXYBUTYRATE COUNTERACTS THE DELETERIOUS EFFECTS OF A SATURATED HIGH-FAT DIET ON SYNAPTIC AMPA RECEPTORS AND COGNITIVE PERFORMANCE

This study shows that beta-hydroxybutyrate (BHB) improves AMPA receptor levels and cognitive performance in mice exposed to a high-fat diet.

Impairments in hippocampal oscillations accompany the loss of LTP induced by GIRK activity blockade

The paper shows that blocking GIRK activity disrupts hippocampal oscillations and converts LTP to LTD, leading to pathological oscillations.

Systematic characterization of a non-transgenic Aβ1-42 amyloidosis model: synaptic plasticity and memory deficits in female and male mice

This study characterizes the effects of Aβ1-42 injection on memory and synaptic plasticity in male and female mice, finding long-lasting impairments in both sexes.

Spatial memory training reverses GirK channels modulation in the transgenic APPSw,Ind Alzheimer's disease mouse model

The paper shows that spatial memory training in APPSw,Ind mice reverses Aβ-induced reductions in hippocampal GirK2 and SNX27 expression, suggesting a potential therapeutic approach for early AD.

Basal G-protein-gated inwardly rectifying potassium (Kir3/GirK) channels activity governs synaptic plasticity that supports dorsal hippocampus-dependent cognitive functions

This study shows that modulating basal GirK channel activity in the dorsal hippocampus affects synaptic plasticity and cognitive functions by altering neural excitability and long-term plasticity processes.