Aditi Mukherjee

Bayesian adaptive experimental design for efficient microbial genome-wide association studies

This paper introduces BASS-GWAS, a Bayesian method for efficient microbial GWAS, identifying causal loci with fewer phenotyped isolates than random sampling.

Fluoroquinolone resistance-conferring gyrA variants alter the fitness cost and potentiate the resistance of the zoliflodacin resistance mutation gyrB D429N in Neisseria gonorrhoeae

This study shows that gyrA variants from ciprofloxacin resistance increase zoliflodacin resistance and fitness cost of the gyrB D429N mutation in N. gonorrhoeae.

In vitro evaluation of the activity of pairwise combinations of zoliflodacin, gepotidacin, and ciprofloxacin against Neisseria gonorrhoeae

The paper evaluates the in vitro activity of pairwise antibiotic combinations against Neisseria gonorrhoeae, finding no evidence of antagonism.

Zoliflodacin and gepotidacin cross-resistance in Neisseria gonorrhoeae

This study shows that the gyrBD429N mutation in Neisseria gonorrhoeae confers cross-resistance to gepotidacin and has variable fitness effects across strains.

A genome-wide overexpression screen identifies TbFOP, whose overexpression disrupts transcription termination in Trypanosoma brucei

This study identifies TbFOP as a gene whose overexpression disrupts transcription termination and causes cell-cycle defects in Trypanosoma brucei.

Quantifying the impact of antibiotic use and genetic determinants of resistance on bacterial lineage dynamics

This study quantifies how antibiotic use and genetic resistance determinants affect bacterial lineage dynamics using a Bayesian model and Neisseria gonorrhoeae isolates.