David Helekal

Bayesian adaptive experimental design for efficient microbial genome-wide association studies

This paper introduces BASS-GWAS, a Bayesian method for efficient microbial GWAS, identifying causal loci with fewer phenotyped isolates than random sampling.

Fluoroquinolone resistance-conferring gyrA variants alter the fitness cost and potentiate the resistance of the zoliflodacin resistance mutation gyrB D429N in Neisseria gonorrhoeae

This study shows that gyrA variants from ciprofloxacin resistance increase zoliflodacin resistance and fitness cost of the gyrB D429N mutation in N. gonorrhoeae.

Diversity and evolution of a phase-variable multi-locus antigen in Neisseria gonorrhoeae

The paper uses long-read sequencing to analyze opa gene diversity in Neisseria gonorrhoeae genomes, revealing high variability and rapid evolution of these genes.

Zoliflodacin and gepotidacin cross-resistance in Neisseria gonorrhoeae

This study shows that the gyrBD429N mutation in Neisseria gonorrhoeae confers cross-resistance to gepotidacin and has variable fitness effects across strains.

Quantifying the impact of antibiotic use and genetic determinants of resistance on bacterial lineage dynamics

This study quantifies how antibiotic use and genetic resistance determinants affect bacterial lineage dynamics using a Bayesian model and Neisseria gonorrhoeae isolates.

Simulating structurally variable Nuclear Pore Complexes for Microscopy

The paper introduces a simulation pipeline to generate structurally variable synthetic NPCs for benchmarking image analysis methods and understanding NPC variability in SMLM data.