William Roman

This study shows that declining NOX4 in skeletal muscle with age disrupts NFE2L2 adaptive homeostasis, leading to muscle dysfunction and systemic aging, which can be mitigated by sulforaphane or exercise.

This paper develops a 3D tumor-on-a-chip platform to study and test drugs that block breast cancer cell intravasation, showing that Dactolisib reduces intravasation without harming endothelial cells.