A decline in skeletal muscle NOX4 abrogates adaptive homeostasis and exacerbates ageing
Chrysovalantou E. Xirouchaki, Esther García-Domínguez, Eamon Coughlan, Meagan J. McGrath, Saveen Giri, Shuwei Liang, Florian Wiede, Anne Bigot, Junichi Sadoshima, Mari Carmen Gómez‐Cabrera, Andrew Philp, Marcus Moberg, William Apró, William Roman, Christina Anne Mitchell, Tony Tiganis
This study shows that declining NOX4 in skeletal muscle with age disrupts NFE2L2 adaptive homeostasis, leading to muscle dysfunction and systemic aging, which can be mitigated by sulforaphane or exercise.
Science Advances · Jun 10, 2026Peer-reviewedPhysiology