Jan Großbach

Esophageal adenocarcinoma relapse after chemoradiation is dominated by a basal-like subtype

The paper identifies a basal-like subtype in esophageal adenocarcinoma associated with relapse after chemoradiation and poor survival.

Enhancing the biological insight from limited proteolysis-coupled mass spectrometry

The paper introduces a framework to deconvolve LiP-MS signals and infer protein structural changes using data from three species.

No evidence that synonymous mutations in yeast genes are mostly deleterious

The paper reanalyzes data from Shen et al. to argue that most synonymous mutations in yeast genes are not deleterious, challenging their original conclusions about fitness effects.

Large-scale changes of molecular network states explain complex traits

The paper identifies a central state transition in yeast molecular networks linked to PKA and TOR signaling, showing how genetic variants can cause global or local molecular changes affecting multiple cellular traits.

A natural variant of the sole pyruvate kinase of fission yeast lowers glycolytic flux triggering increased respiration and oxidative-stress resistance but decreased growth

The paper identifies a natural variant in fission yeast Pyk1 that reduces glycolytic flux, increases respiration, and enhances oxidative-stress resistance but decreases growth.

Integration of transcriptome, proteome and phosphoproteome data elucidates the genetic control of molecular networks

This study integrates transcriptome, proteome, and phosphoproteome data from yeast to show how genetic variation affects molecular networks and cellular growth traits, with phosphorylation playing a key role.

Detection of epistatic interactions with Random Forest

This paper develops three methods to detect epistasis using Random Forest, outperforming existing approaches in simulated and real yeast datasets.