Linxuan Li

Utilizing Non-Invasive Prenatal Test Sequencing Data Resource for Human Genetic Investigation

The paper develops methods for analyzing low-depth NIPT sequencing data to accurately estimate allele frequencies and genetic effect sizes, enabling population genetic studies.

Genetic studies of gestational diabetes mellitus in 21,813 Chinese women

This study identifies four genome-wide significant SNPs associated with GDM in Chinese women and develops an early prediction model using clinical and genetic indicators.

Multi-trait genome-wide association study in 34,394 Chinese women reveals the genetic architecture of plasma metabolites during pregnancy

This study identifies 30 novel metabolite-gene associations in 34,394 Chinese pregnant women and finds pleiotropy and causal relationships between metabolites and diseases.

Genetic analysis of 104 pregnancy phenotypes in 39,194 Chinese women

This study performs a large-scale genetic analysis of 104 pregnancy phenotypes in 39,194 Chinese women, identifying 407 trait-locus associations and uncovering novel genetic insights into pregnancy-related traits.

cfGWAS reveal genetic basis of cell-free DNA features

This study conducts the first GWAS on cell-free DNA (cfDNA) features in pregnant women, identifying 84 genetic loci and revealing causal relationships between hematological indicators and cfDNA biology.

A High-resolution Haplotype-resolved Reference Panel Constructed from the China Kadoorie Biobank Study

The paper constructs a high-resolution haplotype-resolved reference panel from the China Kadoorie Biobank study and demonstrates its superior performance in imputing microarray data compared to existing panels.

A Chinese host genetic study discovered type I interferons and causality of cholesterol levels and WBC counts on COVID-19 severity

This study identifies cholesterol levels and WBC counts as causal factors for COVID-19 severity through GWAS and MR analysis, and highlights type I interferon pathways in disease mechanisms.