Huanhuan Zhu

Utilizing Non-Invasive Prenatal Test Sequencing Data Resource for Human Genetic Investigation

The paper develops methods for analyzing low-depth NIPT sequencing data to accurately estimate allele frequencies and genetic effect sizes, enabling population genetic studies.

Multi-trait genome-wide association study in 34,394 Chinese women reveals the genetic architecture of plasma metabolites during pregnancy

This study identifies 30 novel metabolite-gene associations in 34,394 Chinese pregnant women and finds pleiotropy and causal relationships between metabolites and diseases.

cfGWAS reveal genetic basis of cell-free DNA features

This study conducts the first GWAS on cell-free DNA (cfDNA) features in pregnant women, identifying 84 genetic loci and revealing causal relationships between hematological indicators and cfDNA biology.

A Chinese host genetic study discovered type I interferons and causality of cholesterol levels and WBC counts on COVID-19 severity

This study identifies cholesterol levels and WBC counts as causal factors for COVID-19 severity through GWAS and MR analysis, and highlights type I interferon pathways in disease mechanisms.

Testing and controlling for horizontal pleiotropy with the probabilistic Mendelian randomization in transcriptome-wide association studies

This paper introduces PMR-Egger, a probabilistic Mendelian randomization method to test and control horizontal pleiotropy in transcriptome-wide association studies, showing improved type I error control and power.