The paper shows that apical spectrin organizes actin filament bundles in C. elegans to pattern cuticle ridges, and its loss disrupts ridge formation and matrix delamination.

PLoS Genetics · Jul 16, 2026Peer-reviewedDevelopmental Biology

CDR2 is a dynein adaptor recruited by kinectin to regulate ER sheet organization

Vanessa Teixeira, Kashish Singh, José B. Gama, Matilde Moreira, Ricardo Celestino, Ana Xavier Carvalho, Paulo S. Pereira, Carla M. C. Abreu, Tiago J. Dantas, Andrew P. Carter, Reto Gassmann

This study identifies CDR2 as a dynein adaptor recruited by kinectin to regulate ER sheet organization and shows its role in centrosomal clustering and ER sheet stacking.

The Journal of Cell Biology · Jun 6, 2025Peer-reviewedCell Biology

PIG-1 MELK-dependent phosphorylation of nonmuscle myosin II promotes apoptosis through CES-1 Snail partitioning

Hai Wei, Eric J. Lambie, Daniel S. Osório, Ana Xavier Carvalho, Barbara Conradt

The paper identifies PIG-1 MELK's role in promoting apoptosis by partitioning CES-1 Snail during neuroblast division in C. elegans.

PLoS Genetics · Sep 18, 2020Peer-reviewedDevelopmental Biology

Flow-independent accumulation of motor-competent non-muscle myosin II in the contractile ring is essential for cytokinesis

DS Osorio, FY Chan, J Saramago, J Leite, AM Silva, AF Sobral, R Gassmann, AX Carvalho

This study shows that motor activity of non-muscle myosin II is essential for cytokinesis, independent of actin flows, by analyzing C. elegans embryos with motor mutants.

bioRxiv · May 31, 2018 · PreprintCell Biology