Kashish Singh

In situ cryo-ET of mammalian embryos reveals cytoplasmic lattices contain ubiquitin-charged E2-E3 ligase assemblies

The paper uses cryo-ET to reveal that cytoplasmic lattices in mouse embryos are ubiquitin-charged E2-E3 ligase assemblies involved in protein modification during development.

Cryo-EM structures of Egl-BicD-RNA complexes reveal how diverse mRNAs are selected for subcellular localization

The paper presents cryo-EM structures of Egl-BicD-RNA complexes to show how diverse mRNAs are selected for subcellular localization through shape, sequence, and structured RNA elements.

CDR2 is a dynein adaptor recruited by kinectin to regulate ER sheet organization

This study identifies CDR2 as a dynein adaptor recruited by kinectin to regulate ER sheet organization and shows its role in centrosomal clustering and ER sheet stacking.

Molecular mechanism of dynein-dynactin activation by JIP3 and LIS1

This study determines the cryo-EM structure of dynein-dynactin with LIS1 and JIP3, revealing how these regulators enable complex formation and function.