Ole Paulsen

NeuroSuite provides a non-invasive platform for long-term electrophysiological monitoring of brain organoids, revealing neural network development and activity changes.

This study examines how Mecp2 deficiency affects microscale cortical network topology and dynamics in a Rett syndrome mouse model, finding slower development and reduced connectivity.

This study identifies homophilic wiring as a principle governing neuronal network topology in vitro, outperforming traditional models in explaining connectivity patterns.

The paper identifies three distinct subpopulations of L1 NDNF interneurons in mice that show opposite activation patterns during NREM sleep oscillations, with implications for memory consolidation.

MEA-NAP analyzes microscale functional connectivity and network dynamics from MEA recordings in neuronal cultures, revealing differences in topology and network development.

This study shows dopamine increases protein synthesis in hippocampal neurons, enabling dopamine-dependent long-term potentiation through a distinct signaling pathway.

The paper introduces PseudoSort, a machine learning algorithm for spike sorting, and applies it to MEA data from hippocampal neurons exposed to monomeric Tau, revealing its impact on neuronal activity.

This paper develops a low-latency system for assigning single-neuron identities from neural signals, enabling real-time applications in brain-machine interfaces.

The paper shows that dopamine-induced postsynaptic bursts enable input-specific LTP in hippocampal synapses, enhancing associative plasticity of temporally discontiguous inputs.

This study compares how reward locations are encoded in dorsal and ventral hippocampus during navigation, finding distinct coding strategies in each region.

This study shows that cholinergic activation at the goal location impairs spatial memory and suppresses sharp wave-ripples, while enhancing theta-gamma oscillations during sleep in mice.

The paper investigates how neural coactivity encodes dynamic memory in mice, finding that contingency discrimination relies on emergent coactivity patterns rather than individual neuron tuning.

This study shows that cerebral organoids cultured at the air-liquid interface form functional nerve tracts with diverse morphologies and connectivity.

The paper shows that basal forebrain and brainstem cholinergic neurons differentially affect amygdala circuits and behavior through distinct mechanisms.