Tomomi Kiyomitsu

Balanced RCC1 activity organizes the specialized spindle midplane during cleavage divisions

This study shows that balanced RCC1 GEF activity is essential for organizing the specialized spindle midplane during early vertebrate cleavage divisions.

KIFC1 overexpression induces monopolar spindles by preventing centrosome separation during rapid cleavage divisions

This study shows that KIFC1 overexpression in medaka embryos causes monopolar spindles by preventing centrosome separation, leading to chromosome mis-segregation and embryonic lethality.

Local fluidization of an active cytoplasmic gel partitions large cells

The paper shows that cytoplasm in early embryos behaves as a locally switchable active material, enabling long-range transport of components during cleavage.

Spatiotemporal organization of dynein in bulk cytoplasm promotes aster growth and positioning in large embryos

The paper investigates how dynein organization in bulk cytoplasm coordinates aster growth and centrosome positioning during cleavage in large embryos.

CDK1-dependent N-terminal NuMA phosphorylation promotes dynein-dynactin-NuMA assembly for accurate chromosome segregation

This study shows CDK1-dependent phosphorylation of NuMA's N-terminus is essential for dynein-dynactin-NuMA complex formation, ensuring accurate chromosome segregation.

Ran-GTP assembles a specialized spindle structure for accurate chromosome segregation in medaka early embryos

This study identifies a specialized Ran-GTP-driven spindle structure in medaka embryos that ensures accurate chromosome segregation during early cleavage divisions.