Chromatin as a Coevolutionary Graph: Modeling the Interplay of Replication with Chromatin Dynamics
Sevastianos Korsak, Krzysztof H. Banecki, Karolina Buka, Abhishek Agarwal, Joanna Borkowska, Haoxi Chai, Piotr J. Górski, Yijun Ruan, Dariusz Plewczynski
The paper introduces RepliSage, a framework that dynamically integrates replication timing, loop extrusion, and compartmentalization to simulate chromatin architecture during the cell cycle.
bioRxiv · Mar 31, 2025 · PreprintBioinformatics