Taco Willem Kuijpers

Characterization of a heterogenous activated B cell compartment arising early after antigen exposure preceding long-lived memory B cell formation

The paper characterizes early antigen-specific B cell responses after vaccination, identifying distinct clusters with different contraction dynamics and potential roles in memory B cell formation.

A 5-transcript signature for discriminating viral and bacterial etiology in pediatric pneumonia

The paper identifies a 5-transcript signature in blood samples that distinguishes bacterial from viral pneumonia with high accuracy.

Kawasaki Disease patient stratification and pathway analysis based on host transcriptomic and proteomic profiles

This study stratifies Kawasaki Disease patients using transcriptomic and proteomic profiles, finding KD responses resemble bacterial infections but with distinct features suggesting alternative triggers.

Genetic Analyses of Blood Cell Structure for Biological and Pharmacological Inference

This study performs GWAS on blood cell flow-cytometry phenotypes, identifies variant-trait associations, and links them to cellular structures and disease mechanisms.

Viral and bacterial infection elicit distinct changes in plasma lipids in febrile children

This study identifies distinct lipidomic changes in febrile children with bacterial vs. viral infections, showing potential for metabolic biomarkers to aid in clinical diagnosis.

GRID - Genomics of Rare Immune Disorders: a highly sensitive and specific diagnostic gene panel for patients with primary immunodeficiencies

The paper introduces a diagnostic gene panel called GRID for primary immunodeficiencies, showing high sensitivity and specificity in identifying genetic variants across 279 genes.

Temporal population structure of invasive Group B Streptococcus during a period of rising disease incidence shows expansion of a CC17 clone

The paper uses whole genome sequencing to analyze invasive GBS isolates in the Netherlands and identifies the expansion of a CC17 sub-lineage, CC17-1A, as correlated with increased disease incidence.

Estimating parasite load dynamics to reveal novel resistance mechanisms to human malaria

The paper estimates parasite load dynamics in malaria to identify host resistance mechanisms, finding novel roles for proteases and detrimental effects of interferon response.

Efficient production of erythroid, megakaryoid and myeloid cells, using single cell-derived iPSC colony differentiation

This paper introduces a standardized, feeder-free protocol to efficiently produce erythroid, megakaryoid, and myeloid cells from single-cell-derived iPSC colonies without pre-purification or transcription factor overexpression.

Epigenomic and functional dynamics of human bone marrow myeloid differentiation to mature blood neutrophils

The paper maps the epigenomic and functional changes during human neutrophil differentiation from bone marrow progenitors to mature cells, revealing key regulatory mechanisms.

Genome-wide Analysis of Differential Transcriptional and Epigenetic Variability Across Human Immune Cell Types

The paper measures and compares transcriptional and epigenetic variability across immune cell types and finds neutrophils exhibit higher variability linked to immune pathways and environmental exposure.