Kirsten Nielsen

The paper uses single-cell RNA sequencing to show that Th1-like CD4 T-cells with CTLA-4 expression control latent C. neoformans infection, and CTLA-4 suppression of Th2 activation is beneficial.

This study identifies alternatively activated myeloid cells as drivers of extracellular fungal persistence in pulmonary granulomas through T helper 2 cell signaling.

This study identifies Itr4, a novel inositol transceptor in Cryptococcus neoformans, which regulates inositol and glucose metabolism and fungal virulence.

This study compares proteomic profiles of Cryptococcus neoformans clinical strains to identify differences between latent and lethal infections.

The paper identifies 40 Cryptococcus neoformans genes associated with human immune response and disease outcomes using clinical and genomic data from Ugandan patients.