Maggie P. Wear

Calcium triggers Cryptococcus neoformans aggregation by forming coordination bonds with capsular glucuronoxylomannan

This paper investigates how calcium triggers Cryptococcus neoformans aggregation through coordination bonds with glucuronoxylomannan, revealing its role in capsule structure and host interaction.

An Inositol Receptor Orchestrates Carbon Utilization and Fungal Virulence

This study identifies Itr4, a novel inositol transceptor in Cryptococcus neoformans, which regulates inositol and glucose metabolism and fungal virulence.

Unexpected variability in laboratory and clinical assays used to quantify Cryptococcus neoformans polysaccharide.

This study compares laboratory and clinical assays for measuring cryptococcal polysaccharide, finding that structural variability among strains affects assay sensitivity and results.

Three annotated chromosome-level de novo genome assemblies of Lomentospora prolificans provide evidence for a chromosomal translocation event

This study presents three chromosome-level genome assemblies of Lomentospora prolificans, revealing a chromosomal translocation event between strains.

On the relationship between serotype, chemotype and genotype for Cryptococcus spp. including a method for including polysaccharide structure in strain characterization

This paper examines the relationship between serotype, chemotype, and genotype in Cryptococcus spp., finding no strong correlation between these classifications and GXM motif expression, and introduces a new method for polysaccharide characterization.

Proteins associated with Cryptococcus spp. extracellular polysaccharides are implicated in virulence, capsule integrity, and biofilm formation.

This study identifies four proteins associated with cryptococcal exopolysaccharides that affect virulence, capsule integrity, and biofilm formation through mutant analysis and mass spectrometry.

Semi-synthetic glycoconjugate vaccine candidate against Cryptococcus neoformans

This paper presents two semi-synthetic glycoconjugate vaccines targeting Cryptococcus neoformans GXM, showing immunogenicity and cross-reactivity in mice.

Human and murine Cryptococcus neoformans infection selects for common genomic changes in an environmental isolate.

The paper shows that environmental Cryptococcus neoformans strains undergo genomic and phenotypic changes during mammalian infection, suggesting animal virulence drives genetic adaptation.