Paradoxical Th1 activation and CTLA-4 regulation is beneficial during latent cryptococcosis
Minna Ding, Jenny M. Drnevich, J. Marina Yoder…·Kirsten Nielsen
The paper uses single-cell RNA sequencing to show that Th1-like CD4 T-cells with CTLA-4 expression control latent C. neoformans infection, and CTLA-4 suppression of Th2 activation is beneficial.