Author

Matthew C. Radey

University of Washington

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Genetics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:bacteria (other)· 2 Research Focus:host-pathogen & immune response· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Assay:ChIP-seq· 1 Research Focus:development & morphogenesis· 1 Assay:metagenomics· 1

Frequent Co-Authors

Joseph D. MougousiD· 3 shared Snow Brook PetersoniD· 3 shared Beth A. SheniD· 2 shared Kelsi M. PenewitiD· 2 shared Larry A. GallagheriD· 2 shared Savannah K BertolliiD· 2 shared Stephen J. SalipanteiD· 2 shared Andrew L. GoodmaniD· 1 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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3 shared papersMicrobiology

Joseph D. MougousORCID

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3 papers

Recent·Most cited

The type VI secretion system governs strain maintenance in a wild mammalian gut microbiome

Beth A. Shen, Kyle L. Asfahl, Bentley Lim, Savannah K Bertolli, Samuel S. Minot, Matthew C. Radey, Kelsi M. Penewit, Billy Ngo, Stephen J. Salipante, Christopher D. Johnston, Snow Brook Peterson, Andrew L. Goodman, Joseph D. Mougous

This study shows the type VI secretion system (T6SS) in Bacteroides acidifaciens helps maintain its presence in a wild mouse gut microbiome by antagonizing other Bacteroidales, but its effect depends on ecological context.

eLife · Sep 15, 2026Peer-reviewedMicrobiology

A conserved electron transport chain sensitizes Bacteroides to a pore-forming type VI secretion toxin

Hannah K. Ratner, Brandon D Duong, Peng Miao, Savannah K Bertolli, Beth A. Shen, Uma Mitchell, Larry A. Gallagher, Matthew C. Radey, Snow Brook Peterson, Joseph D. Mougous

The paper identifies the Rnf electron transport chain as a susceptibility determinant for Bte2 pore-forming toxins in Bacteroides, showing its role in toxin-mediated membrane depolarization during gut colonization.

bioRxiv · Aug 29, 2025 · PreprintMicrobiology

Genome-wide protein-DNA interaction site mapping using a double strand DNA-specific cytosine deaminase

Larry A. Gallagher, Elena Velázquez, Snow Brook Peterson, James C. Charity, FoSheng Hsu, Matthew C. Radey, Michael J. Gebhardt, Marcos H. de Moraes, Kelsi M. Penewit, Jennifer S. Kim, Pia A. Andrade, Thomas LaFramboise, Stephen J. Salipante, Vı́ctor de Lorenzo, Paul A. Wiggins, , Joseph D. Mougous

This paper introduces a method called 3D-seq to map DNA-protein interaction sites in vivo using a modified cytosine deaminase, demonstrating its application in Pseudomonas aeruginosa transcription factors.

bioRxiv · Aug 1, 2021 · PreprintGenetics