High-Throughput De Novo Protein Design Yields Novel Immunomodulatory Agonists
Mohamad H. Abedi, Marc Expòsit, Brian Coventry, Divij Mathew, Shruti Jain, Aditya Krishnakumar, Inna Goreshnik, Sophie L. Gray-Gaillard, Margaret C. Lunn-Halbert, Ta-Yi Yu, Matthias Glögl, Uma Mitchell, Riya Keshri, Jung-Ho Chun, Hannele Ruohola‐Baker, , David A. Baker
The paper designs novel cytokines by fusing computationally generated receptor-binding domains, identifying several that activate signaling pathways and have specific biological effects.
bioRxiv · Oct 12, 2025 · PreprintSynthetic Biology