Anirban Roy

Overexpression of miR-424(322)/-503 induces severe dilated cardiomyopathy by regulating the fatty acid oxidation gene expression program

This study shows that overexpression of miR-424(322)/-503 in the heart causes severe dilated cardiomyopathy by disrupting fatty acid oxidation and metabolic function.

TAK1 regulates skeletal muscle mass, hypertrophic signaling, and metabolic homeostasis in male and female mice

This study shows TAK1 regulates skeletal muscle mass, hypertrophy, and metabolism in both male and female mice by affecting signaling pathways and gene expression.

TAK1 is a key regulator of oncogenic signaling and differentiation blockade in rhabdomyosarcoma

This study identifies TAK1 as a key regulator of oncogenic signaling and differentiation blockade in rhabdomyosarcoma, showing its role in promoting proliferation and inhibiting myogenic differentiation.

Hyperactivation of TAK1 causes skeletal muscle pathology reminiscent of inflammatory myopathies

This study shows that hyperactivation of TAK1 in adult mice causes skeletal muscle pathology similar to inflammatory myopathies, while low activation improves muscle mass.

The TWEAK/Fn14 signaling promotes skeletal muscle wasting during cancer cachexia

This study shows that inhibiting the TWEAK/Fn14 signaling reduces skeletal muscle wasting and tumor growth in cancer cachexia models.