Author

Peng Jiao

Sir Run Run Shaw HospitalORCID 0000-0002-7151-0636Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 1 Approach:experimental assay· 1 Organism:human· 1 Assay:structural biology· 1

Frequent Co-Authors

Chun ZhouiD· 1 shared Hui CheniD· 1 shared Jie Gao· 1 shared Jizhong LouiD· 1 shared Lina CheniD· 1 shared Lu Chen· 1 shared Michael Loran DustiniD· 1 shared Panyu FeiiD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperImmunology

Chun ZhouORCID

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1 paper

Recent·Most cited

PD-1 remodels SHP2 dynamics and drives the non-catalytic inhibition of T cell activation

Panyu Fei, Peng Jiao, Jie Gao, Hui Chen, Yu Zhang, Lu Chen, Peng Wu, Lina Chen, Salvatore Valvo, Michael Loran Dustin, Jizhong Lou, Chun Zhou, Wei Chen

This study reveals that PD-1 remodels SHP2 dynamics to inhibit T cell activation through a non-catalytic mechanism, independent of its phosphatase activity.

bioRxiv · May 22, 2026 · PreprintImmunology