Endo-lysosomal sorting and degradation of Tau mediates glucocorticoid-driven hippocampalmalfunction
João Vaz‐Silva, Patrícia Gomes, Qi Jin, Mei J. Zhu, Viktoriya Zhuravleva, Sebastián Quintremil, Torcato Meira, Joana Margarida Silva, Chrysoula Dioli, Carina Soares‐Cunha, Nikolaos P. Daskalakis, Nuno Sousa, Ioannis Sotiropoulos, Clarissa L. Waites
This study shows that glucocorticoids impair Tau degradation via the Rab35/ESCRT pathway, leading to Tau accumulation and hippocampal dysfunction.
The EMBO Journal · Aug 30, 2018Peer-reviewedNeuroscience