Clarissa L. Waites

This study shows glucocorticoids increase neuronal sEV release by activating nSMase2 through mitochondrial damage and ROS production.

This study shows APOE4 worsens stress hormone-induced tau pathology in the hippocampus through mitochondrial dysfunction and identifies a potential therapeutic target.

The paper identifies a neuron type-specific microexon in Ank3/ankyrin-G that modulates calcium activity and neuronal excitability through alternative splicing.

This study shows that glucocorticoids promote vesicle-free Tau secretion and trans-neuronal Tau spreading in the brain, contributing to Alzheimer's disease progression.

This study shows Rab35 regulates APP and BACE1 trafficking to reduce Aβ production, and its downregulation by stress and aging contributes to amyloidogenesis.

The paper identifies a novel activity-dependent mechanism involving Hrs and KIF13A for axonal transport of ESCRT machinery to facilitate synaptic vesicle protein degradation.

This study shows that glucocorticoids impair Tau degradation via the Rab35/ESCRT pathway, leading to Tau accumulation and hippocampal dysfunction.

This study shows that Parkinson's disease-linked Parkin mutations impair glutamatergic synaptic transmission and plasticity by disrupting NMDA and AMPA receptor trafficking.